Foto_Gamaliel_Lopez-Leal

Dr. Gamaliel López Leal

Profesor-Investigador
Laboratorio de Biología Computacional y Virómica Integrativa (BCVI).
Categoría: Asociado C - SNI: Nivel I
Formación académica:
Licenciatura en Biología, Facultad de Ciencias Biológicas. Universidad Autónoma del Estado de Morelos. 2007.
Doctorado en Ciencias. Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México. 2014.
Posdoctorado, Max Planck Tandem Group in Computational Biology, Universidad de los Andes. 2021.
Email: gamaliel.lopez@uaem.edu.mx
Tel: +52 (777)3297020

       

  1. Análisis de la evolución y diversidad de los profagos y sus hospederos mediante herramientas computacionales.
  2. Caracterización y análisis genómico de bacteriófagos con potencial terapéutico contra bacterias multidrogo resistentes.
  1. Piña-González AM, Castelán-Sánchez HG, Hurtado-Ramírez JM, López-Leal G*. Campylobacter prophage diversity reveals pervasive recombination between prophages from different Campylobacter species. Microbiology Spectrum (2023) doi: 10.1128/spectrum.02795-23.
  2. Gómez-Sánchez I, Castelán-Sánchez HG, Martínez-Castilla LP, Hurtado-Ramírez JM, López-Leal G*. Genetic insights into the microevolutionary dynamics and early introductions of human monkeypox virus in Mexico. Archives of Virology (2023). doi: 10.1007/s00705-023-05936-x.
  3. Castelán -Sánchez HG., Martínez -Castilla LP., Sganzerla-Martinez G., Torres-Flores J., López -Leal G. 2022. Genome evolution and early introductions of the SARS -CoV -2 Omicron Variant 2 in Mexico. Virus Evolution doi:10.1093/ve/veac109.
  4. López-Leal G*, Camelo-Valera LC, Hurtado-Ramírez JM, Verleyen J, Castillo-Ramírez S, Reyes-Muñoz A. 2022. Mining of Thousands of Prokaryotic Genomes Reveals High Abundance of Prophages with a Strictly Narrow Host Range. mSystems doi: 10.1128/msystems.00326-22.
  5. Andrade-Martínez J. S., Camelo Valera L. C., Chica Cárdenas L. A., Forero-Junco L., López-Leal G., Moreno-Gallego J. L., ... & Reyes, A. 2022. Computational Tools for the Analysis of Uncultivated Phage Genomes. Microbiology and Molecular Biology Reviews. doi.org/10.1128/mmbr.00004-21.
  6. Arrieta O., Molina-Romero C., Cornejo-Granados F., Marquina-Castillo B., Avilés-Salas A., López-Leal G., Cardona A.F., Ortega-Gómez A., Orozco-Morales M., Ochoa-Leyva A., Hernandez-Pando R. 2022. Clinical and pathological characteristics associated with the presence of the IS6110 Mycobacterim tuberculosis transposon in neoplastic cells from non-small cell lung cancer patients. Sci Rep. doi: 10.1038/s41598-022-05749-z.
  7. Cornejo-Granados F., López-Leal G., Mata-Espinosa G., Barrios-Payán J., Marquina-Castillo B., Equihua-Medina E., Zatarain-Barrón L. Z., Molina-Romero C., Hernández-Pando R., Ochoa-Leyva A. 2021. Targeted RNA-Seq reveals the M. tuberculosis transcriptome from an in vivo infection model. Biology.
    doi.org/10.3390/biology10090848.
  8. López-Leal G., Bikel S., Cornejo-Granados F., Gallardo-Becerra L., García- López R., Sánchez F., Equihua-Medina E., Ochoa-Romo J.P., López-Contreras B.E., Canizales-Quinteros S., Hernández-Reyna A., Mendoza-Vargas A., Ochoa-Leyva A., 2021. Gut dsDNA ViromeShows Diversity and Richness Alterations Associated to Childhood Obesity and Metabolic Syndrome. IScience.
    doi.org/10.1016/j.isci.2021.102900.
  9. Cerezo-Cortés M. I., Rodríguez-Castillo J. G., López-Leal G., Mata-Espinosa D. A., Bini E. I., Marquina–Casitllo B. N., Barrios Payan J., Zatarain-Barrón Z. L., Bobadilla del Valle M., Cornejo-Granados F., Ochoa-Leyva A., Murcia M. I. & Hernández-Pando R. 2021. Profiling the immune response to Mycobacterium tuberculosis Beijing family infection: a perspective from the transcriptome.
    Virulence. doi:10.1080/21505594.2021.1936432.
  10. Luna-Valdeza L., Chenge-Espinosa M., Hernández-Muñoza A., Cordoba E., López-Leal G., Castillo-Ramírez S., León P. 2021. Reassessing the evolution of the 1- deoxy-D-xylulose 5-phosphate synthase family suggests a possible novel function for the DXS class 3 proteins Plant Science.
    doi.org/10.1016/j.plantsci.2021.110960.
  11. López-Leal G*., Reyes-Muñoz A., Santamaria R.I., Pérez-Monter C., Castillo- Ramírez S. 2021. Novel Vieuvirus from multidrug resistance Acinetobacter baumannii.
    Archives of Virology. doi: 10.1007/s00705-021-05010-4
  12. Godinez-Vidal D., López-Leal G., Covarrubias A.A., Reyes J.L. 2020. Early events leading to water deficit responses in the liverwort Marchantia polymorpha.
    Environmental and Experimental Botany. doi.org/10.1016/j.envexpbot.2020.104172.
  13. Zatarain-Barrón Z. L., Ramos-Espinosa O., Marquina-Castillo B., Barrios-Payán J., Cornejo-Granados F., Maya-Lucas O., López-Leal G., Molina-Romero C., Anthony R. M., Ochoa-Leyva A., De La Rosa-Velázquez I. A., Rebollar-Vega R. G., Warren R. M., Mata-Espinosa D. A., Hernández-Pando R., and van Soolingen D. 2020. Evidence for the Effect of Vaccination on Host-Pathogen Interactions in a Murine Model of Pulmonary Tuberculosis by Mycobacterium tuberculosis. Frontiers in immunology. doi.org/10.3389/fimmu.2020.00930.
  14. Arredondo-Hernández R., Schmulson M., Orduña P., López-Leal G., Zarate A. M., Alanis-Funes G., Alcaraz L. D., Santiago-Cruz R., Cevallos M. A., Villa A. R., Ponce-de-León Rosales S., López-Vidal Y., 2020. Consorcio Mexicano para el Estudio del Microbioma Humano. Mucosal Microbiome Profiles Polygenic Irritable Bowel Syndrome in Mestizo Individuals. Frontiers in Cellular and Infection Microbiology. doi:10.3389/fcimb.2020.00072.
  15. López-Leal G, Santamaria R.I., Cevallos M.A., Gonzalez V., Castillo-Ramírez S. 2020.
    Prophages Encode Antibiotic Resistance Genes in Acinetobacter baumannii.
    Microbial Drug Resistance. doi:10.1089/mdr.2019.0362.
  16. Mateo-Estrada V., Graña-Miraglia L., López-Leal G., Castillo-Ramírez S. 2019.
    Phylogenomics reveals clear cases of misclassification and genus-wide phylogenetic markers for Acinetobacter. Genome Biology and Evolution. doi.org/10.1093/gbe/evz178.
  17. López-Leal G., Zuniga-Moya J.C., Castro-Jaimes S., Graña-Miraglia L., Pérez- Oseguera Á., Reyes-García H.S., Gough-Coto S.D., Pavón-Madrid R., Bejarano S.A., Ferrera A., Castillo-Ramírez S., Cevallos M.A. 2019. Unexplored Genetic Diversity of Multidrug- and Extremely Drug-Resistant Acinetobacter baumannii Isolates from Tertiary Hospitals in Honduras. Microbial Drug Resistance. doi: 10.1089/mdr.2018.0311.
  18. López-Leal G., Cornejo-Granados F., Hurtado M. J., Mendoza-Vargas A., Ochoa-Leyva A. 2018. Functional and taxonomic classification of a greenhouse water drain metagenome. Standards in Genomic Sciences. doi.org/10.1186/s40793-018-0326-y.
  19. Graña-Miraglia L., Arreguín-Pérez C., López-Leal G., Muñoz A., Pérez- Oseguera A., Miranda-Miranda E., Cossío-Bayúgar R., Castillo-Ramírez S. 2018. Phylogenomics picks out the par excellence markers for the species phylogeny in the genus Staphylococcus. PeerJ. doi.org/10.7717/peerj.5839
  20. Lopez-Zavala A. A., Guevara-Hernandez E., Vazquez-Lujan H. L., Sanchez-Paz A., Garcia-Orozco D. K, Contreras-Vergara A. C., López-Leal G., Arvizu-Flores A. A., Ochoa-Leyva A., Sotelo-Mundo R. R. 2018. A novel thymidylate synthase from the Vibrionales, Alteromonadales, Aeromonadales, and Pasteurellales (VAAP)
    clade with altered nucleotide and folate binding sites. PeerJ. doi.org/10.7717/peerj.5023.
  21. López-Leal G., Cevallos M.A., Castillo-Ramírez S. 2016. Evolution of a sigma factor: an all-in-one of gene duplication, horizontal gene transfer, purifying selection and promoter differentiation. Frontiers in Microbiology. doi:10.3389/fmicb.2016.00581.
  22. Mucito-Varela E., Castillo-Rojas G., Cevallos M. A., Lozano L., Merino E., López- Leal G., López-Vidal Y. 2016. Complete Genome Sequence of Helicobacter pylori Strain 7C Isolated from a Mexican Patient with Chronic Gastritis. Genome Announcements. doi:10.1128/genomeA.01512-15.
  23. Mucito-Varela E., Castillo-Rojas G., Cevallos M. A., Lozano L., Merino E., López-Leal G., López-Vidal Y. 2016. Complete genome sequence of Helicobacter pylori strain 7C isolated from a Mexican patient with chronic gastritis. Genome Announcements. doi:10.1128/genomeA.01503-15.
  24. López-Leal G*., Tabche M.L., Castillo-Ramírez S., Mendoza-Vargas A., Ramírez-Romero M.A., Dávila G. 2014. RNA-Seq analysis of the multipartite genome of Rhizobium etli CE3 shows different replicon contributions under heat and saline shock. BMC Genomics. doi:10.1186/1471-2164-15-770.
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  1. Castelán-Sánchez HG., López-Leal G., Martínez -Castilla LP., Torres-Flores J. 2022. Decodificando la Diversidad del SARS-CoV-2. Ciencias y Humanidades, CONACyT.
Licenciatura:
  1. Dafne Arellano Maciel. Análisis de la historia evolutiva del género Vieuvirus en A. baumannii. Universidad Abierta y a Distancia de México. México, 2023.
  2. Edgar Bernardo Equihua Medina. Identificación y genómica comparativa de bacteriófagos temperados en el viroma de niños sanos, obesos y niños obesos con complicaciones metabólicas. Universidad Autónoma del Estado de Morelos. 2018.